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Issues can arise involving JupyterHub server (or less commonly, command-line Python). These browser and disk quota issues are similar to those seen for R, so see Troubleshooting R/RStudio server issues. If all else fails, submit a help request to our rctf-support@utexas.edu support email.
One issue specific to JupyterHub is getting 503: service unavailable. with the message: try restarting it from the hub after logging in with BRCF credentials. Sometime just clicking on the Restart button will work; if not, try logging in again.