Does a “Run-time error 53” message appear every time you open a Microsoft Word or Powerpoint document?
Users who have Adobe Acrobat 2020 will experience this issue due to an incompatible add-in Acrobat attempts to add into Work and Powerpoint.
The work around to getting rid of these messages is to delete the add-ins:
For PowerPoint: SaveAsAdobePDF.ppam
For Word: linkCreation.dotm
Scenario 1
Opening the Library Folder
Click on the Finder app 
Click on the Go menu, hold down the Option key 
and choose Library.
Deleting the Problem Files v.1
After opening the Library folder, navigate through the following folders:
📁 Group Containers
📁 UB48T346G9.Office
⚠️ (The name may vary, but should end in ".Office")📁 User Content
📁 Startup
Deleting the PowerPoint File
Within the 📁 Startup folder, open the 📁 Powerpoint folder
Delete the file called “SaveAsAdobePDF.ppam”
Deleting the Word File
Within the 📁 Startup folder, open the 📁 Word folder
Delete the file called “linkCreation.dotm”
Restart Microsoft Word and PowerPoint.
Scenario 2
Opening the Computer Folder
Click on the Finder app
Click on the Go menu and choose Computer.
Deleting the Problem Files
After opening the Computer folder, navigate through the following folders:
💻 Macintosh HD
📁 Library
📁 Application Support
📁 Microsoft
📁 Office365
📁 User Content
📁 Startup
Deleting the PowerPoint File
Within the 📁 Startup folder, open the 📁 Powerpoint folder
Delete the file called “SaveAsAdobePDF.ppam”
Deleting the Word File
Within the 📁 Startup folder, open the 📁 Word folder
Delete the file called “linkCreation.dotm”
Restart Microsoft Word and PowerPoint.
Deleting the Add-in in PowerPoint
While having PowerPoint open, click Tools, click Powerpoint Add-ins, Check the SaveAsAdobePDF add-in, click the minus button to remove it, and click OK.
Restart Microsoft PowerPoint.
You’re done! 🎉